Docetaxel (Taxotere, Docefrez)

Docetaxel is a drug used to treat breast cancer. It works by attacking cancer cells. Each cell in the body has a supporting structure called the microtubular network. Docetaxel makes the microtubular network in cancer cells unnaturally stiff, preventing their growth.

Brand names for docetaxel

Availability of docetaxel as a generic drug

Is docetaxel available as a generic drug? No.

Prescription requirement for docetaxel

Uses of docetaxel

Docetaxel is primarily prescribed to treat breast cancer. It is also a second-line treatment for non-small cell lung cancer, prostate cancer, gastric adenocarcinoma, and squamous cell carcinoma of the head and neck.

Side effects of docetaxel

Common side effects of docetaxel include changes in taste, shortness of breath, constipation, decreased appetite, changes in fingernails or toenails, swelling of hands, face, or feet, weakness or tiredness, joint and muscle pain, nausea and vomiting, diarrhea, mouth or lip sores, hair loss, rash, redness and tearing of the eye, and skin reactions at the site of administration. Leakage of docetaxel into tissues can cause tissue damage.

If you experience any side effects that bother you or do not go away, inform your doctor. This is not a complete list of side effects. For more information, consult your doctor or pharmacist.

Dosage of docetaxel

Docetaxel is administered intravenously. The dosage ranges from 60 mg/m2 to 100 mg/m2 every 3 weeks, in combination with other chemotherapy agents. Dexamethasone is given prior to docetaxel to reduce fluid retention and hypersensitivity reactions.

Drug and supplement interactions with docetaxel

Drugs that reduce liver enzyme activity can increase blood levels of docetaxel and its side effects. Examples include ketoconazole, erythromycin, and protease inhibitors such as ritonavir.

Safety of docetaxel during pregnancy and breastfeeding

Docetaxel can harm unborn babies. Women of childbearing potential should use contraception during treatment. Nursing mothers should stop breastfeeding before taking docetaxel.

Other information about docetaxel

Available forms of docetaxel

Injection Concentrate: 20 mg/0.5 ml, 80 mg/2 ml; Injection (Powder): 20 mg/vial, 80 mg/vial

Storage recommendations for docetaxel

Docetaxel concentrate should be stored between 2 C and 25 C (36 F to 77 F), and the powder should be stored between 2 C and 8 C (36 F and 46 F). Keep them in their original package to protect from light.

Summary

Docetaxel (Taxotere, Docefrez) is a medication primarily prescribed for breast cancer. It is also used for non-small cell lung cancer, prostate cancer, gastric adenocarcinoma, and squamous cell carcinoma of the head and neck. Before taking this medication, review its side effects, drug interactions, dosage, and pregnancy safety information.

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