Diamox Brand Side Effects Dosage Uses

Diamox Brand Side Effects Dosage Uses

Diamox

Acetazolamide is a carbonic anhydrase inhibitor used for the following conditions:

  • To remove extra fluid from the body in people with heart failure.
  • Prevention and treatment of altitude sickness.
  • Seizures.
  • Glaucoma.

Side Effects of Diamox

Common side effects include:

  • Paresthesias (tingling, numbness, burning, prickling)
  • Ringing in the ears
  • Hearing problems
  • Loss of appetite
  • Changes in taste
  • Nausea
  • Vomiting
  • Diarrhea
  • Frequent urination
  • Drowsiness
  • Confusion

Other less common side effects include:

  • Transient myopia
  • Sensitivity to light
  • Glucose in the urine
  • Blood in urine
  • Hives
  • Headache
  • Fever
  • Pain at injection site
  • Flushing
  • Anaphylaxis

Possible serious side effects include:

  • Liver problems
  • Flaccid paralysis
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Agranulocytosis
  • Aplastic anemia and other blood disorders
  • Metabolic acidosis
  • Electrolyte imbalance
  • Growth retardation in children
  • Seizures

Dosage for Diamox

For glaucoma: acetazolamide should be used as an adjunct to the usual therapy.

  • The usual recommended dose for open-angle glaucoma ranges from 250 mg to 1 gram per day.
  • The usual recommended dose for secondary glaucoma and preoperative treatment of closed-angle glaucoma is 250 mg every 4 hours.

For seizures:

  • The manufacturer’s suggested total daily dose is 8-30 mg per kg.
  • The optimum range appears to be from 375 to 1000 mg, however, some patients may respond to lower doses.
  • When used with other anti-seizure medication, the starting dose should be 250 mg.
  • To remove excess fluid in patients with congestive heart failure, the starting dose is usually 250 to 375 mg administered once a day in the morning.
  • As tolerance may develop with use, this medication should be skipped for a day to allow the kidneys to recover in patients who stop responding to treatment.
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For excess water retention caused by medication:

  • The usual recommended dose is 250 to 375 mg once a day for one or two days, alternating with a day of rest.

For acute mountain sickness:

  • The usual recommended dose is 500 mg to 1000 mg per day.
  • 1000 mg is recommended in cases of rapid ascent.
  • Treatment should be started 24-48 hours before ascent and continued for 48 hours while at high altitude, or longer as necessary to control symptoms.

Drug Interactions with Diamox

  • Acetazolamide should not be used with other carbonic anhydrase inhibitors such as methazolamide (Neptazane).

Pregnancy and breastfeeding

  • There are no adequate studies evaluating the use of acetazolamide during pregnancy. Evidence of birth defects was observed in animal studies.
  • The use of acetazolamide during breastfeeding should be considered based on the importance of treatment to the mother.

Other Information about Diamox

Available Preparations
  • Oral tablets: 125 and 250 mg
  • Oral capsules extended release (12hr): 500 mg
  • Powder for injection: 500 mg
Storage
  • All oral preparations should be stored at room temperature.
  • Injection acetazolamide should be stored at room temperature before mixing and in the refrigerator after mixing.
Mechanism of Action
  • Carbonic anhydrase is an enzyme that regulates acidity and fluid balance in various organs.
  • In the kidneys and eyes, carbonic anhydrase helps maintain fluid balance.
  • Acetazolamide works as a diuretic and may be used to treat symptoms of acute mountain sickness and certain forms of seizures.

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Summary

Diamox and Diamox Sequels (acetazolamide) is a man-made drug prescribed for the treatment of glaucoma. Side effects include changes in taste, nausea, vomiting, diarrhea, frequent urination, drowsiness, and confusion.

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