Acetaminophen pamabrom pyrilamine Menstrual Cramp Uses Side Effects

Acetaminophen/pamabrom/pyrilamine

Acetaminophen is a pain reliever, pamabrom is a diuretic, and pyrilamine is an antihistamine. The combination relieves various menstrual symptoms including cramps, backache, headache, bloating, water-weight gain, minor aches and pains, and irritability.

The three drugs work in the following ways:

  • Acetaminophen relieves menstrual cramps, backache, headache, and minor pains by blocking pain impulse generation and inhibiting prostaglandin synthesis in the central nervous system. Acetaminophen also reduces fever by acting on the hypothalamus region of the brain.
  • Pamabrom reduces water retention and bloating during menstruation by increasing urine output.
  • Pyrilamine inhibits histamine activity by blocking H1 histamine receptors. It produces sedative and calming effects.

Warnings

  • Do not use if hypersensitive to any of the ingredients.
  • Do not take with any other drug containing acetaminophen.
  • Do not take with monoamine oxidase inhibitor (MAOI) type antidepressant medications.
  • Acetaminophen can damage the liver with prolonged high-dose use.
  • Use with caution in patients with G6PD enzyme deficiency.
  • Use with caution in patients with certain conditions: cardiovascular disease, diabetes, liver disease, increased intraocular pressure or glaucoma, prostate enlargement, and thyroid dysfunction.

Side Effects

Common side effects include:

  • Hives
  • Itchy rash
  • Swelling under the skin and mucous membranes
  • Swelling of the voice box
  • Allergic reaction
  • Blood disorders
  • Discolored urine
  • Blurred vision
  • Sleepiness
  • Dry mouth

Call your doctor immediately if you experience any of the following symptoms or serious side effects:

  • Serious heart symptoms
  • Severe headache, confusion, slurred speech, severe weakness, vomiting
  • Severe nervous system reaction
  • Serious eye symptoms
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This is not a complete list of all side effects. Call your doctor for medical advice about serious side effects. You may also report side effects to the FDA.

Dosages

Acetaminophen/pamabrom/pyrilamine

Capsule

  • 500 mg/25 mg/15 mg

Gel cap

  • 500 mg/25 mg/15 mg

Tablet

  • 500 mg/25 mg/15 mg

Adult:

  • 1-2 capsule/tablet/gel cap orally every 4-6 hours as needed

Pediatric:

  • Safety and efficacy not established

Overdose:

  • Overdose of acetaminophen/pamabrom/pyrilamine can result in liver damage. Seek immediate medical help.
  • Overdose treatment may include administration of N-acetylcysteine.

Drug Interactions

Inform your doctor of all medications you are taking. Never change the dosage of any medication without your doctor’s recommendation.

  • Severe interactions include: metyrapone, dasatinib, probenecid, vaccines

For more information on drug interactions, visit the RxList Drug Interaction Checker.

Always tell your doctor about all medications you use. Check with your doctor if you have any questions about the medication.

Pregnancy and breastfeeding

  • Use during pregnancy only if clearly needed.
  • Use while breastfeeding with caution.
  • Consult your healthcare provider if you are pregnant or breastfeeding.

Additional Information

  • Take as prescribed or as per label instructions.
  • Drink plenty of water while taking this medication.
  • Check product labels carefully to avoid acetaminophen overdose.
  • Discontinue immediately if you develop hypersensitivity reactions.
  • Avoid or limit alcohol intake.
  • Avoid driving and operating heavy machinery while taking this drug.
  • Store safely out of reach of children.
  • In case of overdose, seek immediate medical help or contact Poison Control.

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Summary

Acetaminophen/pamabrom/pyrilamine is an over-the-counter combination medication used for temporary relief of menstrual symptoms. It should not be taken with certain medications. Side effects include hives, rash, swelling, blood disorders, discolored urine, blurred vision, sleepiness, and dry mouth.

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