Synjardy XR: Streamlined Treatment for Type 2 Diabetes
Synjardy XR is a prescription medicine for Type 2 Diabetes Mellitus. It may be used alone or with other medications.
Belonging to the class of drugs known as Antidiabetics, Biguanides; Antidiabetics, SGLT2 Inhibitors, Synjardy XR effectively manages the symptoms of Type 2 Diabetes Mellitus.
This medicine is not recommended for children under 18 years of age, nor for patients with type 1 diabetes mellitus due to the increased risk of diabetic ketoacidosis.
Side Effects of Synjardy XR
LACTIC ACIDOSIS
Metformin-associated lactic acidosis is a rare but serious side effect of Synjardy XR. Symptoms include malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Prompt medical attention is necessary if any of these symptoms occur.
Risk factors for metformin-associated lactic acidosis include renal impairment, certain medications, older age, radiological studies with contrast, surgery, hypoxic states (e.g., congestive heart failure), excessive alcohol intake, and hepatic impairment.
If there is suspicion of metformin-associated lactic acidosis, immediate discontinuation of Synjardy XR is necessary, along with supportive measures in a hospital setting.
Other side effects of Synjardy XR can include hives, difficulty breathing, swelling, genital or rectal irritation, fever, dizziness, nausea, vomiting, and more. Seek medical help if any of these symptoms occur.
Dosage and Administration
Prior To Initiation Of Synjardy XR
Assess renal function before starting Synjardy XR and correct any volume depletion.
Recommended Dosage
The dosage of Synjardy XR is individualized based on the patient’s current regimen:
- For patients on metformin HCl, switch to Synjardy XR with a similar daily dose of metformin HCl and a daily dose of empagliflozin 10 mg.
- For patients on empagliflozin, switch to Synjardy XR with the same daily dose of empagliflozin and a daily dose of metformin HCl extended-release 1000 mg.
- For patients already treated with empagliflozin and metformin HCl, switch to Synjardy XR with the same daily doses of empagliflozin and a similar daily dose of metformin HCl.
Renal Impairment and Contrast Imaging Procedures
Synjardy XR is not recommended for patients with an eGFR less than 45 mL/min/1.73 m². Discontinue Synjardy XR prior to iodinated contrast imaging procedures in certain patients.
Synjardy XR Interactions and Pregnancy/Breastfeeding
Several medications and substances can interact with Synjardy XR. Avoid excessive alcohol intake while taking this medication. Consult with your doctor about potential drug interactions.
The use of Synjardy XR during pregnancy and breastfeeding should be carefully considered. Animal data suggests negative effects on the kidneys, while limited data is available for pregnant women. Properly controlling diabetes during pregnancy is important for the health of both mother and fetus.
In Summary
Synjardy XR is an effective treatment for Type 2 Diabetes Mellitus. It offers streamlined administration and potential benefits, but it also carries the risk of lactic acidosis. For full information and guidance, consult your doctor or pharmacist.
Remember, always follow your doctor’s instructions and report any side effects promptly.
